400

Theory and practice of modern chemical instrumentation.

Coordination chemistry of transition metals; electronic structures of coordination complexes; crystal field theory and ligand field theory; optical and magnetic properties; descriptive chemistry of transition metals; organometallic chemistry; reaction mechanisms.

Physical-chemical basis of life processes. Topics include: structure and function of proteins, carbohydrates, and fats; metabolism of carbohydrates and fats; and metabolic control processes.

Continuation of CHM 453. Emphasis is on biosynthesis of macromolecules. Topics include photosynthesis, metabolism of amino acids, membrane synthesis, nucleic acid and protein biosynthesis, current topics in biochemistry.

The course focuses on organic synthesis and builds upon the material covered in CHM 325 and CHM 326. Important topics are retrosynthetic analysis, protecting groups, and carbon-carbon bond forming reactions, such as advanced enolate chemistry and palladium cross coupling reactions. Important organic chemistry models, such as the Ireland, Zimmerman-Traxler, Cram and Felkin-Ahn models are presented.

Techniques include modern methods for separation and quantitation of biological materials, including centrifugation, high pressure liquid chromatography, spectrophotometry, and gel electrophoresis. Fee: $60.

A survey of modern instrumentation including the use of spectroscopy, electrochemistry and chromatography for quantitative and qualitative analysis. Fee $60.

The lab is taught under the principles of discovery-based learning. The experiments involve syntheses of main group ligands using organometallic chemistry and inert atmosphere techniques (vacuum lines and a glovebox); syntheses of new transition metal complexes and their investigations by spectroscopic methods (UV-vis, multinuclear NMR, FT-IR), electrochemistry, magnetic measurements (magnetic balance), and structural analyses by X-ray diffraction methods (when possible). Fee: $60.

Techniques utilized will include the use of enzymes in PCR, restriction digests, and ligations, as well as overexpression, purification, and characterization of a target protein and related cofactors. Skills in proposal writing will also be developed. Fee: $60

Hands on instruction in the use of computer software and programming for the acquisition, manipulation, and interpretation of chemical data. Fee: $60.

Credit arranged by student in cooperation with faculty.

Special topic seminar. Lectures, panel discussions, student research paper, and oral presentation.

Faculty-directed student research. Before enrolling, students must consult with a faculty member to define the project. May be repeated for credit. Fee: $60 per credit hour.

Intensive field experience in selected chemical industries. Students may receive an IP (In Progress) grade until the completion of their internship. Department permission and chemistry G.P.A. of 3.0 required.

Research, study, or original work under the direction of a faculty mentor, leading to a scholarly thesis document with a public presentation of results. Requires approval of thesis director, department chair, dean, and the director of the honors program, when appropriate.